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FILE - In this March 23, 2021 file photo, pedestrians walk past the New York Stock Exchange in New York's Financial District. Stocks are opening lower on Wall Street after the head of a major vaccine maker expressed concern about how effective current jabs will be against the new variant of the coronavirus. The S&P 500 gave back 0.6%, the Nasdaq slipped 0.3% and the Dow Jones Industrial Average fell 0.9%. European markets were also modestly lower. (AP Photo/Mary Altaffer, File)